This case describes nosocomial transmission of highly pathogenic avian influenza (HPAI) in an immunocompromised resident clinic cat. The feline patient, likely exposed to HPAI via raw meat or fomites from infected poultry, presented with severe respiratory distress, lethargy, and anorexia. Diagnosis was confirmed through molecular testing for influenza A virus. The cat's immunocompromised state exacerbated the infection, leading to a critical condition. This incident highlights the zoonotic potential of HPAI and the critical importance of stringent infection prevention and control measures in veterinary settings, especially when dealing with vulnerable animals. Teaching point: Strict biosecurity protocols are essential to prevent zoonotic disease transmission, even in seemingly controlled environments.